Life-extension therapy: Hesperitin, found in Citrus fruits, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 7/February/2017, 11.01 pm
What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others. What we […]
Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor TNFAIP8L2/TIPE2, inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 7/February/2017, 10.36 pm
Research findings to Therapeutic opportunity: The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may inhibit the expression of tumor suppressor Tumor necrosis factor (TNF)-α-induced protein 8-like 2 (TNFAIP8L2, TIPE2). [easy_payment currency=”USD”] Thereby, it may inhibit cell cycle progression, proliferation, and promote apoptosis of cancer cells. Thus, pharmacological formulations encompassing “MiRNA-9600 activators” may be […]
Regenerative therapy for improving muscle repair and strength in the elderly: Succinate, one of the components in Citric acid cycle, extract decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 7/February/2017, 10.28 pm
Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published in the 30 November 2016 issue of the journal “Nature” [One of the best research journals in General Science with an I.F of 38+] by […]
Natural product-derived therapy for glucose homeostasis and TIIDM: Ellagic acid, found in walnuts, pecans, cranberries, raspberries, and strawberries, among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 7/February/2017, 7.04 am
Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative islet cell types.” This research paper was published in the 12 December 2016 issue of […]
Natural product-based Lifespan extension therapy: Kaemphferol, found in Aloe Vera, among others, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 6/February/2017, 10.48 pm
Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. From research findings to therapeutic opportunity: This study suggests, for the first time, that Kaemphferol, by increasing the […]
Molecular therapy for Bone disorders: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2) inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 6/February/2017, 10.34 pm
Introduction: What they say: A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.” This study was published in the June 25, 2014 Nature [I.F >42] by Prof. Wan Y, Krzeszinski and others from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, […]