Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor PTPN14 (Pez), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 6/February/2017, 10.19 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may inhibit the expression of tumor suppressor PTPN14 (Pez). [easy_payment currency=”USD”] Thereby, it may inhibit cell cycle progression, proliferation, and promote apoptosis of cancer cells. Thus, pharmacological formulations encompassing “MiRNA-9600 activators” may be used to inhibit cancer progression. Details of […]

Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Casuarinin, a hydrolyzable tannin isolated from the bark of Terminalia arjuna Linn. (Combretaceae), decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 6/February/2017, 9.59 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that “Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.”  This research paper was published in the 10 August 2016 issue of the journal […]

Fish Oil-derived therapy for enhancing anti-cancer immunity: Docosahexaenoic acid (DHA), one of the main components of Fish oil, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gen, 6/February/2017, 3.23 pm

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.” This study was published in the 1 December 2016 issue of the journal “Cell” [the number 1 journal in General Biology with […]

Steroid therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Androgen promotes an insulin-sensitized state via up-regulation of its target gene, 6/February/2017, 2.04 pm

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of […]

Natural product-based therapy for Metastatic tumors: Formononetin, an isoflavone found in the roots of astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, increases the expression of tumor suppressor interleukin IL1B and promotes apoptosis of tumor cells via down regulation of its target gene, 6/February/2017, 1.40 pm

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant […]

Molecular therapy for glucose homeostasis and TIIDM: Ethyl Pyruvate (PE) increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 6/February/2017, 5.48 am

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative islet cell types.” This research paper was published in the 12 December 2016 issue of […]