Ideas

Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor PTPN14 (Pez), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 6/February/2017, 10.19 pm
Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor PTPN14 (Pez), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 6/February/2017, 10.19 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may inhibit the expression of tumor suppressor PTPN14 (Pez). [easy_payment currency=”USD”] Thereby,…

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Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Casuarinin, a hydrolyzable tannin isolated from the bark of Terminalia arjuna Linn. (Combretaceae), decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 6/February/2017, 9.59 pm
Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Casuarinin, a hydrolyzable tannin isolated from the bark of Terminalia arjuna Linn. (Combretaceae), decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 6/February/2017, 9.59 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that…

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Fish Oil-derived therapy for enhancing anti-cancer immunity: Docosahexaenoic acid (DHA), one of the main components of Fish oil, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gen, 6/February/2017, 3.23 pm
Fish Oil-derived therapy for enhancing anti-cancer immunity: Docosahexaenoic acid (DHA), one of the main components of Fish oil, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gen, 6/February/2017, 3.23 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2…

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Steroid therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Androgen promotes an insulin-sensitized state via up-regulation of its target gene, 6/February/2017, 2.04 pm
Steroid therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Androgen promotes an insulin-sensitized state via up-regulation of its target gene, 6/February/2017, 2.04 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose…

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Natural product-based therapy for Metastatic tumors: Formononetin, an isoflavone found in the roots of astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, increases the expression of tumor suppressor interleukin IL1B and promotes apoptosis of tumor cells via down regulation of its target gene, 6/February/2017, 1.40 pm
Natural product-based therapy for Metastatic tumors: Formononetin, an isoflavone found in the roots of astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, increases the expression of tumor suppressor interleukin IL1B and promotes apoptosis of tumor cells via down regulation of its target gene, 6/February/2017, 1.40 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Molecular therapy for glucose homeostasis and TIIDM: Ethyl Pyruvate (PE) increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 6/February/2017, 5.48 am
Molecular therapy for glucose homeostasis and TIIDM: Ethyl Pyruvate (PE) increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 6/February/2017, 5.48 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that…

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