Ideas

October 5, 2017

Published by admin_auro at October 5, 2017

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Natural product-based therapy for ageing-associated diseases: A therapeutic mix encompassing β-cryptoxanthin, Oleanolic acid and Withaferin A (β-COW), isolated from Sweet peppers/Papaya, Olive oil, Ashwagandha, respectively, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 6/October/2017, 1.16 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]

October 5, 2017

Published by admin_auro at October 5, 2017

Categories

Ideas
Pain

Natural product-based PD-1 pathway activation for Pain therapy: Silymarin, isolated from M.Thistle, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gen, 06/October/2017, 1.03 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]

October 5, 2017

Published by admin_auro at October 5, 2017

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Small molecule-based therapy for TIIDM, Metabolic defects and Longevity: L-deprenyl, used in the treatment of Parkinson’s disease and depression, increases Sirtuin-4 expression, augments insulin secretion, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 06/October/2017, 12.49 am

Introduction: What they say A study from the “Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC […]

October 4, 2017

Published by admin_auro at October 4, 2017

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Natural product-derived therapy for inflammation and arthritis: Nordihydroguaiaretic acid (NDGA), isolated from creosote, among others, increases IL-9 levels, increases proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up regulation of its target genes, 05/October/2017, 1.37 am

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that […]