Ideas

Life-extension therapy: Orphan nuclear receptor Nur77/NGFI-B inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 5/February/2017, 6.47 pm
Life-extension therapy: Orphan nuclear receptor Nur77/NGFI-B inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 5/February/2017, 6.47 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

read more

Natural product-based therapy for Metastatic tumors: Formononetin, an isoflavone found in the roots of astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, increases the expression of tumor suppressor gene PDCD4 and promotes apoptosis of tumor cells via down regulation of its target gene, 5/February/2017, 6.23 pm
Natural product-based therapy for Metastatic tumors: Formononetin, an isoflavone found in the roots of astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, increases the expression of tumor suppressor gene PDCD4 and promotes apoptosis of tumor cells via down regulation of its target gene, 5/February/2017, 6.23 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

read more

Molecular therapy for Myocardial Infarction: Ethyl Pyruvate (EP) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 5/February/2017, 8.51 am
Molecular therapy for Myocardial Infarction: Ethyl Pyruvate (EP) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 5/February/2017, 8.51 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

read more

Natural product-derived therapy for glucose homeostasis and TIIDM: Guggulsterone, isolated from Commiphora mukul resin, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 5/February/2017, 7.30 am
Natural product-derived therapy for glucose homeostasis and TIIDM: Guggulsterone, isolated from Commiphora mukul resin, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 5/February/2017, 7.30 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that…

read more

Natural product therapy for Breast Cancer: Scoparone, found in Yin-chen-Saatgut-artemisia-scoparia, increases the level of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 4/February/2017, 11.59 pm
Natural product therapy for Breast Cancer: Scoparone, found in Yin-chen-Saatgut-artemisia-scoparia, increases the level of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 4/February/2017, 11.59 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA…

read more

Natural product-derived therapy for triple-negative breast tumors: American ginseng increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 4/February/2016, 11.42 pm
Natural product-derived therapy for triple-negative breast tumors: American ginseng increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 4/February/2016, 11.42 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as…

read more
Start Typing