Ideas

August 11, 2017

Natural product-derived therapy for tuberculosis:  Dihydroartimisin, isolated from Artemesia Annua L, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 12/August/2017, 12.05 am

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]
August 11, 2017

Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: β-caryophyllene, isolated from black pepper among others, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 11/August/2017, 11.56 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
August 11, 2017

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Ivermectin, the anti-parasitic drug, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 11/August/2017, 11.41 pm

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the efficacy of […]
August 11, 2017

Molecular therapy for anxiety and depression: Clomipramine (Brand name: Anafranil among others), the antidepressant drug, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 11/August/2017, 11.27 pm

Introduction: What they say: A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department […]
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