Ideas – Page 531

October 4, 2017

Published by admin_auro at October 4, 2017

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Natural product-derived combination therapy for blood-stage Plasmodium infection: A therapeutic mix encompassing Artemisinin, Chloroquine, and Amodiaquine [ACA] decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 5/October/2017, 12.50 am

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]

October 4, 2017

Published by admin_auro at October 4, 2017

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Cancer
Ideas

Natural product-derived therapy for prostate cancer bone metastasis: A therapeutic mix encompassing Nimbolide and Solasodine, isolated from Azadirachta indica, and Solarium melongena, respectively, inhibits the expression of Monoamine oxidase A (MAOA), inhibits Shh-IL6-RANKL signaling network, suppresses tumor-stromal interactions, reduces prostate cancer metastasis and prolongs survival via up regulation of its target gene, 04/October/2017, 11.59 pm

Introduction: What they say: A study from the Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA shows that “MAOA-Dependent Activation of […]

October 4, 2017

Published by admin_auro at October 4, 2017

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Ideas
Pain

Natural product-based PD-1 pathway activation for Pain therapy: Osthole, an O-methylated coumarin isolated from Cnidium monnieri, Angelica archangelica and Angelica pubescens, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gen, 04/October/2017, 11.14 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]

October 4, 2017

Published by admin_auro at October 4, 2017

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Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Mevastatin, Desipramine, EGCG, Decitabine, Biochanin A, Temozolomide (TMZ) , Cholecalciferol, PEITC, & Linalool (MDEBTCPL) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 04/October/2017, 11.04 pm

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands has identified […]