Ideas

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Isoliquiritigenin, isolated from Licorice (Glycyrrhiza glabra), decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 23/January/2017, 11.52 pm
Natural product-derived PD-1 pathway blockade for Human cancer therapy: Isoliquiritigenin, isolated from Licorice (Glycyrrhiza glabra), decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 23/January/2017, 11.52 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

read more

Immune enhancement therapy: Insulin increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 23/January/2017, 11.38 pm
Immune enhancement therapy: Insulin increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 23/January/2017, 11.38 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate…

read more

MiRNA therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: MiR-208a promotes an insulin-sensitized state via up-regulation of its target gene, 23/January/2017, 11.33 pm
MiRNA therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: MiR-208a promotes an insulin-sensitized state via up-regulation of its target gene, 23/January/2017, 11.33 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose…

read more

Anticancer therapy targeting the cancer stem cells: MiRNA-9600 increases the expression of tumor suppressor INK4a, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 23/January/2016, 11.21 pm
Anticancer therapy targeting the cancer stem cells: MiRNA-9600 increases the expression of tumor suppressor INK4a, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 23/January/2016, 11.21 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may increase the expression of tumor suppressor INK4a. [easy_payment currency=”USD”] Thereby, it…

read more

Molecular therapy for Myocardial Infarction: Linagliptin (brand name: BI-1356/Tradjenta), an inhibitor of dipeptidylpeptidase-4 (DPP-4), inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 22/January/2017, 11.22 pm
Molecular therapy for Myocardial Infarction: Linagliptin (brand name: BI-1356/Tradjenta), an inhibitor of dipeptidylpeptidase-4 (DPP-4), inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 22/January/2017, 11.22 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

read more

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: β-Caryophyllene oxide (CPO), found in oregano, cinnamon, clove, and black pepper among others, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 22/January/2017, 11.11 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: β-Caryophyllene oxide (CPO), found in oregano, cinnamon, clove, and black pepper among others, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 22/January/2017, 11.11 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

read more
Start Typing