Natural product Anti-telomerase cancer therapy: Hesperetin, found in citrus fruits, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 4/November/2016, 10.35 pm

What they say: Introduction:  The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. What we say:  In connection with the finding presented above, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports […]

Natural product therapy for Myocardial Infarction: Abelmoschus M. flower extract improves myocardial function after myocardial infarction via up-regulation of PNUTS, 4/November/2016, 8.31 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Myocardial Infarction: Abelmoschus M. flower extract […]

Natural product-based PD-1 pathway blockade for Human cancer therapy: Moringa oleifera (MO) extract inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 4/November/2016, 8.23 am

Introduction:What they say:  A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in the 28 September 2016 issue of Cancer Discovery (one of the best journals in Cancer […]

Natural product-based therapy against Pulmonary bacterial pathogens: Hibiscus syriacus extract increases IL-17R, and Chemokine CXCL5 expression and protects against infections casued by bacterial pathogen K. pneumoniae via up-regulation of its target gene, 3/November/2015, 6.24 pm

Introduction: What they say A study from the Richard King Mellon Foundation Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA shows that “IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.” This research paper was published […]

Natural product-based PD-1 pathway blockade for Human cancer therapy: Epigallocatechin-3-gallate, one of the major constituents of green tea, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 3/November/2016, 8.38 am

Introduction:What they say:  A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in the 28 September 2016 issue of Cancer Discovery (one of the best journals in Cancer […]

Natural product Immune enhancement therapy: Abelmoschus M. flower extract increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 3/November/2016, 8.08 am

Introduction: What they say:  A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of  24.973] by Drs. […]