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Ideas

November 18, 2016

Natural product-based Cardiac rejuvenation therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 18/November/2015, 7.04 am

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure […]
November 18, 2016

Natural product therapy for Breast Cancer: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Phormium tenaxm, and Luffa amara among others, increases the level of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 18/November/2015, 6.07 am

Introduction: What they say:  A study from the Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann […]
November 17, 2016

Natural product therapy for tuberculosis: Curcumin, one of the main components of turmeric, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 17/November/2016, 10.58 pm

Introduction: What they say:  A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in […]
November 17, 2016

Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-9600 increases the expression of tumor suppressor p53 homologue TAp63 and induces regression of p53-mutated human tumors via down regulation of its target gene, 17/November/2016, 10.27 pm

Significance: Cancer suppressor p53 is mutated in more than 50% of human cancers of different origin, while its pathway is altered in about 80% of tumors. […]
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