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Ideas

November 15, 2016

Natural product therapy for KRAS-mutant lung cancer: Grifolin, an antitumor natural product from the mushroom Albatrellus confluens, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 15/November/2016, 9.31 pm

What they say:  A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted […]
November 15, 2016

Natural product therapy for Breast Cancer: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, increases the levels of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses epithelial-to-mesenchymal transition and the progression of metastasis, and supports tumor relapse-free survival in breast cancer patients, 15/November/2015, 1.04 pm

What they say:  A study from the Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann Arbor, […]
November 15, 2016

Natural product therapy for glucose homeostasis and TIIDM: Kaempferol, found in Allium cepa, Aloe vera, Coccinia grandis, Moringa oleifera & Rosmarinus officinalis among others, increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 15/November/2015, 12.03 pm

What they say:  A study from the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02130, USA; Laboratory of Gene Regulation and Signal […]
November 14, 2016

Natural product-based anti-ageing therapy: Hesperidin, found in Citrus fruits, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 14/November/2015, 10.52 pm

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA […]
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