Ideas

Natural product-derived therapy for Metastatic cancers: Naringenin, a flavonoid found in grapefruit, oranges, and tomatoes (skin) among others, decreases the expression of PMP22 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 28/February/2017, 6.46 am

National Science day special ********* We wish every one a very happy National Science day. On this special occasion, we are happy to announce that ideas posted […]

Small molecule-based PD-1 pathway blockade for Human cancer therapy: Metformin, the widely used drug in the treatment of TIIDM, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 27/February/2017, 9.27 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]

Natural product-based therapy for Metabolic diseases: Fla-CN, a flavonoid derivative of tiliroside, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene.., 27/February/2017, 6.32 pm

Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” […]

Vitamin-based therapy for Metastatic cancers: Ascorbate, found abundantly in Kakadu plum/murunga, and camucamu among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 27/February/2017, 8.36 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
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