Ideas

February 24, 2017
Published by admin_auro at February 24, 2017
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Combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: 15-deoxy-delta(12,14)-prostaglandin J2 (PGJ2) decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 24/January/2017, 11.01 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that 15-deoxy-delta(12,14)-prostaglandin J2 (PGJ2), by increasing the expression of its target genes, it may: (i) decrease the […]
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February 24, 2017
Published by admin_auro at February 24, 2017
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Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of stem cell gene/reprogramming protein Nanog, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 24/January/2016, 10.53 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may decrease the expression of protein that is […]
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February 24, 2017
Published by admin_auro at February 24, 2017
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Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of Sprouty-1/2 (SPRY-1/2) and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 24/February/2017, 10.31 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of […]
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February 24, 2017
Published by admin_auro at February 24, 2017
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Natural product-derived therapy for Diabetic Kidney disease: Extracts of Piper betle leaves (PBLs) decrease VEGF-B expression, inhibit lipid accumulation in Podocytes, promote insulin signalling in Podocytes, induce insulin sensitivity, ameliorate renal dysfunction and alleviate diabetic kidney disease via down regulation of its target gene, 24/February/2017, 12.06 pm

Introduction: What they say A study from the Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden shows that […]
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