Ideas

February 16, 2017

Natural product-derived therapy for glucose homeostasis and TIIDM: Oleanolic acid, isolated from Java apple, Olive Europaea, and Phytolacca americana among others, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 16/February/2017, 9.17 am

Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in […]
February 15, 2017

Molecular therapy for Myocardial Infarction: Long ncRNA HULC ((H ighly U pregulated in L iver C ancer)) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 15/February/2017, 11.15 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
February 15, 2017

Natural product therapy for Diabetic Kidney disease: Shikonin, isolated from Zicao (also known as Purple gromwell), decreases VEGF-B expression, inhibits lipid accumulation in Podocytes, promotes insulin signalling in Podocytes, induces insulin sensitivity, ameliorates renal dysfunction and alleviates diabetic kidney disease via down regulation of its target gene, 15/February/2017, 11.07 pm

Introduction: What they say A study from the Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden shows that […]
February 15, 2017

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Combination of Resveratrol and Metformin decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 15/February/2017, 6.17 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
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