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Ideas

October 4, 2016

Therapeutic insights into PD-1 pathway blockade for Human cancer therapy: Olea europaea leaf extract (OLE) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down regulation of its target gene, 4/October/2016, 10.35 pm

A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression […]
October 4, 2016

Natural product Life-extension therapy: Calycosin, isolated from the root of Astragalus membranaceous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 04/October/2016, 7.57 am

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 […]
October 3, 2016

Natural product therapy targeting aberrant Lipid synthesis in Human cancers: Ursolic acid, one of the main components of Tulsi and apple peels, suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production in cancer cells and tumor progression via up regulation of its target gene, 3/October/2016, 11.37 am

A recent study from Rutgers Cancer Institute of New Jersey, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey, USA shows that “Cullin3–KLHL25 ubiquitin […]
October 3, 2016

Natural product therapy for KRAS-mutant lung cancer: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 03/October/2016, 10.59 am

A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung […]
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