Ideas

January 13, 2017

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Persimmon tannin extract decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 13/December/2016, 11.45 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
January 13, 2017

Natural product-derived therapy for Metastatic human tumors: Boehmenan, a lignan from the Chinese medicinal plant Clematis armandi, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 13/January/2017, 11.27 pm

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen […]
January 13, 2017

Natural product therapy for glucose homeostasis and TIIDM: Sulforaphane, found in Broccoli sprouts and Cauliflower, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensisitity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 13/January/2017, 11.01 pm

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]
January 13, 2017

Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Guttiferone K (GUTK), found in Garcinia cambogia, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 13/January/2017, 10.31 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Guttiferone K (GUTK), by increasing the expression of its target genes, it may: (i) decrease the […]
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