Ideas

February 4, 2017
Published by admin_auro at February 4, 2017
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Molecular therapy for N-Myc-overexpressing tumors: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Phormium tenax, and Luffa amara among others, increases the levels of tumor suppressor proteins, TAp63, TAp63 and Fbw7 (SCF Fbw7 ubiquitin ligase), inhibits the expression of pro-survival proteins N-Myc, Cyclin-E and Mcl-1, and stalls the progression of N-Myc-overexpressing cancers via down regulation of its target gene, 4/February/2017, 11.25 pm

Introduction: What they say A study from the Zhongnan Hospital of Wuhan University, Wuhan 430071, China; and Medical Research Institute, Wuhan University, Wuhan 430071, China shows […]
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February 4, 2017
Published by admin_auro at February 4, 2017
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Natural product-derived PD-1 pathway blockade for Human cancer therapy: Genistein, found in Soy and Amur (Maackia amurensis) among others, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 4/February/2017, 11.16 pm

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]
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February 4, 2017
Published by admin_auro at February 4, 2017
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Natural product-derived therapy for enhancing anti-cancer immunity: Celastrol, isoalted from Thunder God Vine/Tripterygium Wilfordii, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 4/February/2017, 11.02 pm

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that […]
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February 4, 2017
Published by admin_auro at February 4, 2017
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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Epigallocatechin-3-gallate (EGCG), one of the main components of Green tea, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 4/February/2017, 5.50 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
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