Ideas

January 5, 2017
Published by admin_auro at January 5, 2017
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Natural product-derived therapy for enhancing anti-cancer immunity: Withaferin A, one of the main components of Acnistus arborescens, and Ashwagantha among others, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 5/January/2017, 11.42 am

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that […]
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January 4, 2017
Published by admin_auro at January 4, 2017
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Vitamin-based therapy for triple-negative breast tumors: 1α,25-dihydroxyvitamin D(3)/Calcitriol increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 4/January/2017, 10.15 pm

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that […]
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January 4, 2017
Published by admin_auro at January 4, 2017
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Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 4/January/2017, 10.01 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Bergapten (5-methoxypsoralen), by increasing the expression of its target genes, it may: (i) decrease the expression […]
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January 4, 2017
Published by admin_auro at January 4, 2017
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Life-extension therapy: Glimepride (Trade name: Amaryl), a sulphonylurea antidiabetic drug, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 4/January/2017, 5.49 pm

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
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