Ideas

January 23, 2017
Published by admin_auro at January 23, 2017
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MiRNA therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: MiR-208a promotes an insulin-sensitized state via up-regulation of its target gene, 23/January/2017, 11.33 pm

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The […]
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January 23, 2017
Published by admin_auro at January 23, 2017
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Anticancer therapy targeting the cancer stem cells: MiRNA-9600 increases the expression of tumor suppressor INK4a, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 23/January/2016, 11.21 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may increase the expression of tumor suppressor INK4a. […]
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January 22, 2017
Published by admin_auro at January 22, 2017
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Molecular therapy for Myocardial Infarction: Linagliptin (brand name: BI-1356/Tradjenta), an inhibitor of dipeptidylpeptidase-4 (DPP-4), inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 22/January/2017, 11.22 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
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January 22, 2017
Published by admin_auro at January 22, 2017
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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: β-Caryophyllene oxide (CPO), found in oregano, cinnamon, clove, and black pepper among others, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 22/January/2017, 11.11 pm

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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