Ideas

December 25, 2016
Published by admin_auro at December 25, 2016
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Natural product-derived therapy for enhancing anti-cancer immunity: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 25/December/2016, 10.00 pm

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that […]
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December 25, 2016
Published by admin_auro at December 25, 2016
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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: PAPD5 (Poly(A) RNA Polymerase D5, Non-Canonical) increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 25/December/2016, 9.18 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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December 24, 2016
Published by admin_auro at December 24, 2016
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Natural product-derived therapy for Human Leukemias: Boehmenan, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 25/December/2016, 12.03 am

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms […]
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December 24, 2016
Published by admin_auro at December 24, 2016
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Molecular therapy for Myocardial Infarction: KGF inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 24/December/2016, 11.35 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
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