Ideas

January 21, 2017

Published by admin_auro at January 21, 2017

Categories

Ideas

Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: The Wnt-β-catenin pathway promotes an insulin-sensitized state via up-regulation of its target gene, 21/January/2017, 7.50 am

Introduction: What they say: A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The […]

January 20, 2017

Published by admin_auro at January 20, 2017

Categories

Ideas

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Bergamottin (BGM), a natural Furanocoumarin found in grapefruit juice, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 20/January/2017, 11.13 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

January 20, 2017

Published by admin_auro at January 20, 2017

Categories

Ideas

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Indole-3-carbinol (I3C), found in broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 20/January/2017, 10.47 pm

Introduction:What they say: A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]

January 20, 2017

Published by admin_auro at January 20, 2017

Categories

Ideas

Natural product-derived Immune enhancement therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 20/January/2017, 10.27 pm

Introduction: What they say: A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]