Ideas

January 20, 2017

Published by admin_auro at January 20, 2017

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Ideas

Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of oncomiR MiR-17-92, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 20/January/2016, 10.17 pm

Research findings to Therapeutic opportunity: The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may inhibit the expression of oncomiR MiR-17-92. [easy_payment […]

January 20, 2017

Published by admin_auro at January 20, 2017

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Cardiac rejuvenation therapy: β-Cellulin (BTC), a ligand for the EGF receptor, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 20/January/2017, 10.00 pm

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated […]

January 19, 2017

Published by admin_auro at January 19, 2017

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Natural product-derived PD-1 pathway blockade for Human cancer therapy: Alantolactone, present in Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 19/January/2017, 11.58 pm

Introduction:What they say: A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]

January 19, 2017

Published by admin_auro at January 19, 2017

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Ascochlorin (ASC), an isoprenoid antibiotic, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 19/January/2017, 11.36 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]