Ideas

January 3, 2017
Published by admin_auro at January 3, 2017
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Natural product-derived Immune enhancement therapy: Oleanolic acid, found in Syzygium S. or Jawa apple and among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 3/January/2017, 1.03 pm

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]
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January 3, 2017
Published by admin_auro at January 3, 2017
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Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Puerarin, isolated from Cucurbita texana, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 3/January/2017, 11.53 am

What is known? I have published earlier that Puerarin may suppress the expression of Tripeptidyl Peptidase 1 (TPP1) and Telomerase and inhibit cancer progression.  From Research findings […]
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January 2, 2017
Published by admin_auro at January 2, 2017
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Molecular therapy for Bone disorders: ARIH2 nhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 2/January/2017, 11.00 pm

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone […]
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January 2, 2017
Published by admin_auro at January 2, 2017
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Small molecule-based PD-1 pathway blockade for Human cancer therapy: HOXA10 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 2/January/2017, 10.53 pm

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]
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