Ideas

January 13, 2017
Published by admin_auro at January 13, 2017
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Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Guttiferone K (GUTK), found in Garcinia cambogia, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 13/January/2017, 10.31 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Guttiferone K (GUTK), by increasing the expression of its target genes, it may: (i) decrease the […]
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January 13, 2017
Published by admin_auro at January 13, 2017
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Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor Interleukin-1β (IL-1β), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 13/January/2016, 10.26 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of Interleukin-1β (IL-1β). [easy_payment […]
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January 13, 2017
Published by admin_auro at January 13, 2017
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Natural product-derived Life-extension therapy: Sauchinone, an antioxidant lignan found in Saururus chinensis, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/January/2017, 10.19 am

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
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January 13, 2017
Published by admin_auro at January 13, 2017
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Immune enhancement therapy: Estradiol (E2) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 13/January/2017, 10.10 pm

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]
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