Ideas

December 17, 2016
Published by admin_auro at December 17, 2016
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Lifespan extension therapy: Amiodarone, an antiarrhythmic drug, decreases aging-related decline in muscle function and enhances the longevity of mammals via down regulation of Myostatin, 17/December/2016, 11.04 am

Introduction:  A study from the Department of Orthopaedic Surgery, University of Michigan Medical School, USA; and Department of Molecular & Integrative Physiology, University of Michigan Medical School, […]
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December 17, 2016
Published by admin_auro at December 17, 2016
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Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses. γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 17/December/2016, 10.19 am

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]
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December 16, 2016
Published by admin_auro at December 16, 2016
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Natural product-derived therapy for overcoming chemoresistance in Human cancers: Genistein increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 16/December/2016, 10.35 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Genistein, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; […]
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December 16, 2016
Published by admin_auro at December 16, 2016
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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: MiR-29a increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 16/December/2016, 10.21 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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