Ideas

January 3, 2017

Published by admin_auro at January 3, 2017

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Ideas

Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Puerarin, isolated from Cucurbita texana, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 3/January/2017, 11.53 am

What is known? I have published earlier that Puerarin may suppress the expression of Tripeptidyl Peptidase 1 (TPP1) and Telomerase and inhibit cancer progression. From Research findings […]

January 2, 2017

Published by admin_auro at January 2, 2017

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Molecular therapy for Bone disorders: ARIH2 nhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 2/January/2017, 11.00 pm

Introduction: What they say: A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone […]

January 2, 2017

Published by admin_auro at January 2, 2017

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Small molecule-based PD-1 pathway blockade for Human cancer therapy: HOXA10 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 2/January/2017, 10.53 pm

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]

January 2, 2017

Published by admin_auro at January 2, 2017

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Molecular therapy for Myocardial Infarction: Sitagliptin, a Dipeptidyl peptidase-4 (DPP-4) inhibitor and an anti-hyperglycemic drug, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 2/January/2017, 10.35 pm

What they say: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, […]