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December 23, 2016
Published by admin_auro at December 23, 2016
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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Kukoamine A, a spermine alkaloid derived from Cortex lycii radicis, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 23/December/2016, 9.46 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
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December 23, 2016
Published by admin_auro at December 23, 2016
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Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: Eriocitrin, a flavonoid found in Lemons, decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 23/December/2016, 1.56 pm

Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This […]
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December 22, 2016
Published by admin_auro at December 22, 2016
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Molecular therapy for Myocardial Infarction: NMI (N-myc interactor) inhibit DNA damage responses, increase telomerase expression, inhibit telomere shortening, and promote cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 22/December/2016, 11.03 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
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December 22, 2016
Published by admin_auro at December 22, 2016
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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Garlic increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 22/December/2016, 10.53 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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