Ideas

January 1, 2017

Published by admin_auro at January 1, 2017

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Ideas

Natural product-derived therapy for tuberculosis: Gingerol, one of the main components of Ginger, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 1/January/2017, 10.57 pm

Introduction: What they say: A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in […]

January 1, 2017

Published by admin_auro at January 1, 2017

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Ideas

Small molecule-based PD-1 pathway blockade for Human cancer therapy: ARIH2 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 1/January/2017, 10.02 pm

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]

January 1, 2017

Published by admin_auro at January 1, 2017

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Cardiac rejuvenation therapy: 17-β Estradiol (17-βE2) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 1/January/2017, 12.32 pm

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated […]

January 1, 2017

Published by admin_auro at January 1, 2017

Categories

Ideas

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Panax notoginseng saponins, isolated from Panax notoginseng (Burk), increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 1/January/2017, 11.23 am

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]