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December 27, 2016
Published by admin_auro at December 27, 2016
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Natural product-derived Life-extension therapy: Celastrol, found in the root extracts of Tripterygium wilfordii and Celastrus regelii, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 27/December/2016, 11. 45 pm

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows […]
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December 27, 2016
Published by admin_auro at December 27, 2016
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Molecular therapy for N-Myc-overexpressing tumors: BMP4 increases the levels of tumor suppressor proteins, TAp63, TAp63 and Fbw7 (SCF Fbw7 ubiquitin ligase), inhibits the expression of pro-survival proteins N-Myc, Cyclin-E and Mcl-1, and stalls the progression of N-Myc-overexpressing cancers via down regulation of its target gene, 27/December/2015, 11.08 pm

Introduction: What they say A study from the Zhongnan Hospital of Wuhan University, Wuhan 430071, China; and Medical Research Institute, Wuhan University, Wuhan 430071, China shows […]
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December 27, 2016
Published by admin_auro at December 27, 2016
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Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: AbM (Agaricus blazei Murill) decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 27/December/2016, 10.45 pm

Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This […]
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December 27, 2016
Published by admin_auro at December 27, 2016
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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Valproic acid, used in the treatment of epilepsy, bipolar disorder and migraine headaches, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 27/December/2016, 2.55 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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