Ideas

December 15, 2016

Published by admin_auro at December 15, 2016

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Ideas

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Fenofibrate, used in the treatment of hypercholesterolemia or mixed dyslipidemia, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 15/December/2016, 10.22 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

December 14, 2016

Published by admin_auro at December 14, 2016

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Small molecule-based PD-1 pathway blockade for Human cancer therapy: NCYM, a Cis-Antisense Gene of MYCN, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 14/December/2016, 11.01 pm

Introduction:What they say: A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]

December 14, 2016

Published by admin_auro at December 14, 2016

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Natural product-derived Lifespan extension therapy: Theobromine, isolated from Theobroma and commonly found in chocolates, increases life span via up-regulation of its target gene BubR1, 14/December/2016, 10.50 pm

What they say: Introduction: A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]

December 14, 2016

Published by admin_auro at December 14, 2016

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Anti-telomerase cancer therapy: MiR-362-3p suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 14/December/2016, 10.36 pm

Introduction: What they say: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL […]