Ideas

December 19, 2016
Published by admin_auro at December 19, 2016
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Small molecule-based PD-1 pathway blockade for Human cancer therapy: UBTD1 (Ubiquitin domain containing 1) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 19/December/2016, 9.49 pm

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]
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December 19, 2016
Published by admin_auro at December 19, 2016
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Natural product-derived therapy for enhancing anti-cancer immunity: Curcumin analog EF24 decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 19/December/2016, 10.27 am

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that […]
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December 18, 2016
Published by admin_auro at December 18, 2016
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Natural product-derived therapy for overcoming chemoresistance in Human cancers: Honokiol increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 18/December/2016, 11.01 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Honokiol, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; […]
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December 18, 2016
Published by admin_auro at December 18, 2016
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Immune enhancement therapy: Annexin A2 (Anxa2) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 18/December/2016, 10.52 pm

Introduction: What they say:  A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils […]
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