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December 14, 2016
Published by admin_auro at December 14, 2016
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Natural product-derived therapy for Human Leukemias: Cucurbitacin E, found abundantly in Watermelons, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 14/December/2016, 10.19 pm

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms […]
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December 14, 2016
Published by admin_auro at December 14, 2016
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Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor protein Grainyhead transcription factor-3 (GRHL3), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 14/December/2016, 9.49 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor GRHL3. […]
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December 14, 2016
Published by admin_auro at December 14, 2016
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Natural product-derived therapy for overcoming chemoresistance in Human cancers: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 14/December/2016, 9.43 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Cirsiliol, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; […]
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December 14, 2016
Published by admin_auro at December 14, 2016
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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: MiR-411 increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 14/December/2016, 9.28 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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