Ideas

December 14, 2016

Published by admin_auro at December 14, 2016

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Ideas

Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor protein Grainyhead transcription factor-3 (GRHL3), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 14/December/2016, 9.49 pm

Research findings to Therapeutic opportunity: The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor GRHL3. […]

December 14, 2016

Published by admin_auro at December 14, 2016

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Ideas

Natural product-derived therapy for overcoming chemoresistance in Human cancers: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 14/December/2016, 9.43 pm

From Research findings to Therapeutic opportunity: The study presented here suggests that Cirsiliol, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; […]

December 14, 2016

Published by admin_auro at December 14, 2016

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Ideas

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: MiR-411 increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 14/December/2016, 9.28 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

December 14, 2016

Published by admin_auro at December 14, 2016

Categories

Ideas

Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses. Eriocitrin, isolated from lemons, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 14/December/2015, 7.21 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]