Ideas

December 10, 2016

Published by admin_auro at December 10, 2016

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Ideas

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Moringa Olifera extract decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 10/December/2016, 6.34 pm

Introduction:What they say: A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]

December 10, 2016

Published by admin_auro at December 10, 2016

Categories

Ideas

Anti-telomerase cancer therapy: Cancer suppressor VHL (Von Hippel-Lindau) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 10/December/2016, 11.53 am

Introduction: What they say: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 […]

December 10, 2016

Published by admin_auro at December 10, 2016

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Ideas

Natural product-derived therapy for overcoming chemoresistance in Human cancers: Amla extract increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 10/December/2016, 8.51 am

What is known? I have published earlier that Amla extract: (i) increases the levels of tumor suppressor p53, inhibits the proliferation of tumor-initiating cells in breast cancer, […]

December 9, 2016

Published by admin_auro at December 9, 2016

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Ideas

Natural product-derived therapy for brain repair and Lifespan extension: Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa and Artemisia douglassiana Besser, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 9/December/2016, 10.34 pm

What they say: Introduction: A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of […]