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November 24, 2016
Published by admin_auro at November 24, 2016
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Anti-metastasis therapy: MiRNA-9600 increases the expression of metastasis suppressor Sprouty2 and inhibits proliferation, invasion and metastasis of cancer cells via down regulation of its target gene,24/November/2015, 3.38 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of metastasis suppressor […]
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November 24, 2016
Published by admin_auro at November 24, 2016
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MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-1976 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 24/November/2016, 3.33 pm

Introduction:What they say:  A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]
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November 24, 2016
Published by admin_auro at November 24, 2016
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Natural product-derived combo therapy for ACAT1-overexpressing Human cancers: Curcumin and (6)-gingerol (6G) combo, one of the main components of Turmeric and Ginger, respectively, inhibits Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) expression, acetylation of Pyruvate dehydrogenase (PDH) and PDH phosphatase, pyruvate dehydrogenase complex (PDC) formation and tumor growth via down regulation of its target gene, 24/November/2015, 2.57 pm

Introduction: What they say A study from the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, […]
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November 24, 2016
Published by admin_auro at November 24, 2016
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Molecular therapy for Metabolic disorders: MiRNA-152 increases (LXR)-α expression, insulin-secreting cell mass and function via down regulation of its target genes, 24/November/2016, 1.27 pm

Public health relevance:  Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat […]
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