Ideas

November 22, 2016

Published by admin_auro at November 22, 2016

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Ideas

Natural product Life-span extension therapy: Plums (Prunus salicina L) extract increases life span by suppressing mTOR pathway through up regulation of its target gene, 22/November/2016, 6.10 am

What is known: It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity […]

November 21, 2016

Published by admin_auro at November 21, 2016

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Anti-telomerase cancer therapy: MiRNA-466g suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 21/November/2016, 11.22 pm

Introduction: What they say: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 […]

November 21, 2016

Published by admin_auro at November 21, 2016

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MiRNA-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: MiRNA-96 increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 21/November/2016, 8.10 pm

[easy_payment]Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte […]

November 21, 2016

Published by admin_auro at November 21, 2016

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Natural product-based PD-1 pathway blockade for Human cancer therapy: γ-Bisabolene, found in Cardamom among others, decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 21/November/2016, 11.17 am

Introduction:What they say: A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]