Ideas

May 1, 2015

Stretch therapy for pulmonary arterial hypertension: Mechanical stretch inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 1/May/2015, 9.01 am

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in […]
April 30, 2015

Anti-metastasis therapy: MiRNA-134 increases the expression of TPM1 (tropomyosin) and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 30/April/2015, 18.19

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Anti-metastasis therapy: MiRNA-134 increases the expression of TPM1 (tropomyosin) and inhibits migration and invasion of […]
April 26, 2015

Molecular cancer therapy: JunB inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 26/April/2015, 17.16

A study from Karolinska Institutet, Stockholm, Sweden shows that MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.  This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas H, […]
April 24, 2015

MiRNA-based therapy for Preserving β-Cell functioning in DM and for extending life span of humans: MiRNA-137 increases the expression of antiaging and longevity gene Klotho, improves β-Cell function and prevents the development of T2DM via down regulation of its target gene, 24/April/2015, 23.55

Significance:   Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; […]
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