Ideas

April 26, 2015
Published by admin_auro at April 26, 2015
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Molecular cancer therapy: JunB inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 26/April/2015, 17.16

A study from Karolinska Institutet, Stockholm, Sweden shows that MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.  This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas H, […]
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April 24, 2015
Published by admin_auro at April 24, 2015
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MiRNA-based therapy for Preserving β-Cell functioning in DM and for extending life span of humans: MiRNA-137 increases the expression of antiaging and longevity gene Klotho, improves β-Cell function and prevents the development of T2DM via down regulation of its target gene, 24/April/2015, 23.55

Significance:   Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; […]
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April 19, 2015
Published by admin_auro at April 19, 2015
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Sunlight exposure stalls p53-mutated metastatic cancer progression: Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of tumor suppressor p53 homolouge TAp63 and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 19/April/2015, 10.43 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance:  Cancer suppressor p53 is mutated in more than 50% of human cancers of different origin, while its pathway […]
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April 5, 2015
Published by admin_auro at April 5, 2015
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Natural product-based cancer therapy: Ursolic acid, enriched in apples, inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 5/April/2015, 14.23

A study from Karolinska Institutet, Stockholm, Sweden shows that “MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.” This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas […]
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