Myocardial infarction

December 24, 2018

Molecular therapy for heart regeneration and repair: Carvidiol (trade name: Coreg), used to treat congestive heart failure and high blood pressure, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 24/December/2017, 10.38 am

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
December 23, 2018

Molecular therapy for TIIDM and Metabolic defects: Carvedilol (brand name: Coreg), used to treat high blood pressure and congestive heart failure, increases Sirtuin-4 expression, augments insulin secretion, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 23/December/2018, 11.19 pm

Introduction: What they say A study from the “Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC […]
December 23, 2018

Mechanistic insights into how Carvedilol may aid in attenuating pathogenesis-associated with Myocardial infarction: Carvedilol (brand name: Coreg),  used in the treatment of high blood pressure and congestive heart failure, decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up-regulation of its target gene, 23/December/2018, 5.47 pm

Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and […]
December 13, 2018

Molecular Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Valproic acid (brand names: Convulex, depakote, epilim, stavzor and others), a drug used to treat seizures/epilepsy, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 13/December/2018, 11.41 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]