A recent study from the Yale Comprehensive Cancer Center, Yale School of Medicine, Cedar Street, New Haven, Connecticut, USA; Dana-Farber/Brigham and Women’s Cancer Center, Brookline Avenue, Boston, Massachusetts, USA; and others shows that “Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.” This study was published in the 27 November 2014 issue of Nature (the number 1 journal in Science with an impact factor of 42) by Prof Hodi FS, Herbst RS and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Chocolate your way to boost your immunity against cancers: Theobromine, a compound derived from theobroma and commonly found in cocoa and dark chocolates, decreases the expression of PD-1, a suppressor of activation of T-cells, and activates immune system via down regulation of its target gene
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Chocolate your way to boost your immunity against cancers: Theobromine, a compound derived from theobroma and commonly found in cocoa and dark chocolates, decreases the expression of PD-1, a suppressor of activation of T-cells, and activates immune system via down regulation of its target gene, 29/May/2015, 10.14 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance:
It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year.
The study presented here suggests that Theobromine, by decreasing the expression of its target gene, it may suppress the expression of PD-1. Thereby, it may activate immune system and inhibit metastatic progression. Thus, pharmacological formulations encompassing “Theobromine or its analogues“ may be used to inhibit the progression of tumors. Based on this finding, Physicians may consider recommending their cancer patients to consume dark chocolates etc.
Undisclosed information: How Theobromine suppresses the expression of PD-1
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