This year’s Nobel prize winner for Physiology or Medicine Prof. Sudhof C Thomas (from Stanford University, California, USA) has published an article in the Journal Nature (2008) stating that ” Neuroligins and Neurexins link synaptic function to cognitive disease.” In this study, the author explains how: (1) “Neurexins and neuroligins– synaptic cell-adhesion molecules–connect presynaptic and postsynaptic neurons at synapses, mediate signalling across the synapse, and shape the properties of neural networks by specifying synaptic functions“; and (2) synaptic cell adhesion is linked to cognition and its disorders (Sudhof, 2008, Nature).
In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that p53/p63/p73 regulates Neuroligins and Neurexins expression via up regulation of its target miRNAs. This finding provides mechanistic insight into the pathology of autism and other cognitive diseases.
Idea Proposed by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan, Connecting with Nobel’s (Sudhof C Thomas) Cognitive work: p53/p63/p73 regulates Neuroligins and Neurexins expression via up regulation of its target miRNAs, 14/October/2013, 8.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
* Research cooperation
