This year’s Nobel prize winner for Physiology or Medicine Prof. Sudhof C Thomas (from Stanford University, California, USA) has published a paper in the Journal Cell (2011) stating that ” Activity-dependent IGF-1 exocytosis is controlled by the Calcium-sensor synaptotoagmin-10.” This study suggests that deletion of synaptotoagmin-10 results in (i) impaired secretion of IGF-1; (ii) smaller neurons; and (iii) an overall decrease in synapse numbers.
In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that p53/p63/p73 inhibits IGF-1 exocytosis via up regulation of its target miRNAs. This finding suggests that p63/p73/p53 may (i) inhibit IGF-1 secretion through its target miRNAs; and (ii) decrease synapse numbers.
Idea Proposed by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan, Connecting with Nobel’s (Sudhof C Thomas) favorite work: p53/p63/p73 inhibits IGF-1 exocytosis via up regulation of its target miRNAs, 13/October/2013, 22.28, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
* Research cooperation
