A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Diabetic pills can lengthen life span: Acarbose, an antiglycemic drug used in the treatment of non-insulin-dependent Diabetes Mellitus, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 17/April/2015, 10.29 am
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Significance: This study provides mechanistic insights into how Diabetic pills can lengthen life span. Acarbose, by increasing the expression of its target gene, it may decrease the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase). Thereby, it may promote (1) resistance to bone, immune, and motor dysfunction; and (2) insulin sensitivity. Thus, pharmacological formulations encompassing “Acarbose or its analogues“ may be used to extend the life span of an individual.
Citation: Boominathan, Diabetic pills can lengthen life span: Acarbose, an anti-glycemic drug used in the treatment of non-insulin-dependent Diabetes Mellitus, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 18/April/2015, 7.40 am , Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Acarbose decreases the expression of p70S6 Kinase
