Prof. Dr Kouzarides and the Nobel Prize Winner in Physiology/Medicine (2012) Prof Dr Gurdon JB from Cancer Research Gurdon Institute, Cambridge, UK report in the prestigious journal Nature (2014) that “Citrullination regulates pluripotency….”
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Dismantling stem cell network: Tumor suppressor p53 inhibits the embryonic stem cell transcriptional network through induction of its target gene peptidylarginine deiminase-4. Furthermore, Dr Boominathan identifies the mechanism by which p53 and its homologues p63 and p73 regulate citrullination of arginine residues in proteins. This exciting finding explains how stress induced p53 and its homologues TA-p63 and TA-p73 inhibit the pluripotency transcriptional network in normal cells and in cancer cells.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Dismantling stem cell network: Tumor suppressor p53 inhibits the embryonic stem cell transcriptional network through induction of its target gene peptidylarginine deiminase-4, 10/February/2014, 8.34 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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