Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Exercise therapy for Cancer patients: Regular Exercise increases the expression of tumor suppressor p53 via down regulation of MDM2, 20/March/2014, 14.27, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: Cancer suppressor p53 (1) is mutated in 50% of different human tumors; and (2) pathway is rendered inactive in 30% of different tumors. In total, p53’s tumor suppressor function is compromised in 80% of tumors of different origin. This study suggests, for the first time, that regular exercise, by increasing the expression of its target gene, it may augment the expression of tumor suppressor p53. Thereby, it may inhibit cancer development or progression. Based on this finding, Physicians/Oncologists may consider encouraging their cancer patients to undergo regular exercise therapy.
Undisclosed information: How regular exercise augments the expression of the guardian of the genome p53
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