Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., GOD can stall cancer spread: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, inhibits invasion and metastasis by altering protein trafficking via up regulation of tumor suppressor PTPN14 (Pez), 31/March/2015, 8.06 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: The study presented here suggests that Celastrol, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor PTPN14 (Pez). Thereby, it may inhibit the migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing “Celastrol or its analogues” may be used to inhibit the progression of invasive tumors.
Undisclosed information: How Celastrol increases the expression of PTPN14 (Pez)
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