- A study from the Department of Clinical and Molecular Cardiovascular Research, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan; Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan; and JST CREST, Shinjuku-ku Tokyo, Japan has reported that “MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing …”
- This study was published in the 11 June 2014 EMBO Journal by Prof. Ieda M, Muraoka N and others from the Department of Clinical and Molecular Cardiovascular Research, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan.
- On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: High-salt intake inhibits the generation of cardiomyocyte-like cells from differentiated cells: High-salt intake inhibits cardiac reprogramming by increasing Snai expression. This study suggests that high salt-intake, by suppressing the expression of its target gene, it could (1) decrease the number of beating cardiomyocyte-like cells (iCMs); and (2) inhibit cardiac repair. Taken together, this study explains how high-salt intake inhibits the regeneration of cardiac cells and its adverse impact on cardiac repair.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, High-salt intake inhibits the generation of cardiomyocyte-like cells from differentiated cells: High-salt intake inhibits cardiac reprogramming by increasing Snai expression, 19/June/2014, 13.48, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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