Bio-Med Ideas

April 15, 2015

Anti-stress therapy: Sildenafil, a phosphodiestrase-5 inhibitor, increases the expression of MDM2, a negative regulator of stress responsive protein p53, via up regulation of its target gene, 15/April/2015, 9.20 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: Sildenafil is used in the treatment of erectile dysfunction and pulmonary arterial hypertension. Sildenafil, by increasing the expression of its target […]
April 15, 2015

Sunlight exposure stalls metastatic cancer progression : Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of tumor suppressor BTG2 and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 15/April/2015, 9.06 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests a vitamin-based Anti-metastasis therapy. 1α, 25-dihydroxyvitamin D3 (Calcitriol), by increasing the expression of its target genes, […]
April 14, 2015

Natural product-based Immune enhancement therapy: Pear extract increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 14/April/2015, 23.17

A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor […]
April 14, 2015

Molecular therapy for pulmonary arterial hypertension: Vasodilator-stimulated phosphoprotein inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 14/April/2015, 23.09

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in […]
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