Bio-Med Ideas

April 26, 2015

MiRNA-based therapy for pulmonary arterial hypertension: MiRNA-709 inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 26/April/2015, 23.52

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in […]
April 26, 2015

A known drug of an unknown analgesic  function: Metformin, the widely used drug in the treatment of TIIDM,  suppresses the expression of Cyclooxygenase-2 (Cox2) via up regulation of its target gene, 26/April/2014, 23.38

Significance:  Meformin is widely used drug in the treatment of TIIDM, while Cyclooxygenase-2  (COX2) inhibitors  are used to relieve pain. This study suggests, for the first time, that […]
April 26, 2015

Molecular therapy for Metastatic human tumors: Ndfip1 decreases cellular proliferation, invasion and metastasis by increasing the expression of metastasis suppressor TPM1 (Tropomyosin-1) via down regulation of its target gene, 26/April/2015, 18.09

A study from the Cell Pathology Division, The Children’s Hospital of Philadelphia, Philadelphia, USA shows that “TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production […]
April 26, 2015

Molecular cancer therapy: JunB inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 26/April/2015, 17.16

A study from Karolinska Institutet, Stockholm, Sweden shows that MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.  This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas H, […]
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