Bio-Med Ideas

December 31, 2018

Probiotic-based chemotherapy targeting immune-inhibitory receptors and cancer stem cells in chronic myelogenous leukemia (CML) and other metastatic cancers: A pharmaceutical mixture encompassing  Misoprostol, an FDA-approved EP4 agonist and abortion-promoting drug, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as KIPRA, PTPN14, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets CML leukemic stem cells, confers protection against CML and prolongs survival, via up-regulation of its target gene, 31/December/2018, 7.04 pm

Introduction: What they say: A study from the Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA shows […]
December 31, 2018

Molecular therapy for aging-associated diseases and Lifespan extension: Nicotinamide riboside, a pyridine-nucleoside form of vitamin B3 and precursor to NAD+, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging, via down-regulation of its target gene, 31/December/2018, 6.55 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
December 28, 2018

Molecular therapy for diabetes (TIDM): Ramipril (trade names: Altace, Prilace Novapril, Ramitens, Ampril, Corpril, Piramil, Prilinda and others),), a drug used in the treatment of hypertension and cardiac dysfunction, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 28/December/2018, 11.25 pm

Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, […]
December 28, 2018

Probiotics-based regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Probiotic VSL#3 increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 28/December/2018, 11.15 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
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