Bio-Med Ideas

December 28, 2018

Molecular therapy for Diabetes Mellitus: Ramipril (trade names: Altace, Prilace Novapril, Ramitens, Ampril, Corpril, Piramil, Prilinda and others),), a drug used in the treatment of hypertension and cardiac dysfunction, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 28/December/2018, 10.12 pm

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
December 28, 2018

Probiotic-based therapy for glucose homeostasis and TIIDM: Probiotic VSL#3 increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM, via down regulation of its target gene, 28/December/2018, 9.57 pm

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]
December 28, 2018

Molecular regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Ramipril (brand names: Altace, Prilace Novapril, Ramitens, Ampril, Corpril, Piramil, Prilinda and others), a drug used to treat hypertension, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 28/December/2018, 9.36 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
December 26, 2018

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing   lncRNA Hand2-AS1 and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such a SMAD7/CDK2AP1, BIRC5,  p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 26/December/2018, 7.55 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that:  Probiotic-based chemotherapy targeting cancer stem cells […]
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