Bio-Med Ideas

April 20, 2018

Turning on the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor suppressors genes, such as BigH3, TIPE2, PTEN, PDCD4, INK4a, BTG2, TA-p73/p63, TPM1, TIMP3, CCM1/KRIT1 and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 20/April/2017, 2.42 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
April 20, 2018

Bonding your way to live longer: Oxytocin-based anti-ageing and Lifespan extension therapy: Oxytocin (also known as compassion/goodness/bonding hormone), a peptide hormone and neuropeptide known to play a role in empathy, generosity, childbirth and so on, increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 20/April/2018, 12.38 pm

Introduction: What they say  A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, […]
April 20, 2018

Molecular therapy for glaucoma: Valproic acid (brand name: Convulex and others), used in the treatment of epilepsy, bipolar disorder, migraine headaches and others,  increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 20/April/2018,  12.21 pm

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
April 20, 2018

A sweetest way to say no to blood sugar disease: Natural sweetener-based therapy for TIIDM: Phyllodulcin, a natural sweetener 400-800 times sweeter than sugar,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 20/April/2018, 11.11 am

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
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