Bio-Med Ideas

September 3, 2018

Chocolate your way to stay free of pulmonary arterial hypertension (PAH): Monomeric cocoa catechins, one of the components of dark chocolates, inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3, 3/August/2018, 11.36 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]
September 2, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  KISS1, TCF21,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 3/September/2018, 12.23 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 2, 2018

Eating dark chocolate may lower cholesterol and triglyceride levels: Chocolate-based therapy for Non-alcoholic fatty liver disease (NAFLD): Monomeric cocoa catechins, found in dark chocolate, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down-regulation of its target gene, 3/September/2018, 12.15 am

The significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 […]
September 2, 2018

Quercetin-derived compound Tamarixetin may aid in pain therapy: Tamarixetin-based activation of the PD-1 pathway for Pain therapy: Tamarixetin (an O-methylated flavonol), a derivative of quercetin,  increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 2/September/2018, 11.57 pm

 Introduction: What they say:  A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for […]
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