Bio-Med Ideas

August 19, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  Navigator(Nav3), HBP-1, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 19/August/2018, 11.55 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 19, 2018

Revealing the unrevealed function of  the reproductive hormone Relaxin in triglycerides/cholesterol reduction and in the treatment of Non-alcoholic fatty liver disease (NAFLD) : Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature,  promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of NAFLD, via down-regulation of its target gene, 19/August/2018, 11.45 pm

The significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 […]
August 19, 2018

Estradiol functions as a longevity promoter: Estradiol, a female steroid hormone, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 19/August/2017, 11.23 pm

What they say:  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
August 18, 2018

Revealing the unrevealed function of  the reproductive hormone Relaxin in the heart: Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 19/August/2018, 12.35 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of the […]
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