Bio-Med Ideas

July 2, 2018

Bacillus Calmette Guerin (BCG) vaccine-based adjunct therapy for cardiac hypertrophy and fibrosis: BCG vaccine decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function, via up regulation of its target gene, 2/July/2018, 11.13 am

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
July 1, 2018

Bacillus Calmette Guerin (BCG) vaccine-based therapy for pulmonary arterial hypertension: Repurposing tuberculosis vaccine into a pulmonary arterial hypertensive vaccine: BCG, a tuberculosis vaccine, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 1/July/2018, 11.36 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]
July 1, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  TPM1, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 27/June/2018, 11.08 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
July 1, 2018

Bacillus Calmette Guerin (BCG) vaccine-based therapy for blood sugar disease: BCG, a tuberculosis vaccine,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 1/July/2018, 10.55 pm

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
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