Bio-Med Ideas

March 4, 2018

Activation of the PD-1 pathway for Pain therapy: DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin), a synthetic opioid peptide, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 4/March/2017, 11.07 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
March 3, 2018

 A glass of milk a day keeps the cardiac diseases at bay: Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Human or Cow’s milk increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 3/March/2018, 9.40 am

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
March 3, 2018

Molecular therapy for tuberculosis: Carvedilol (brand name: Coreg), used in treatment of congestive heart failure and left ventricular dysfunction, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 3/March/2018, 9.23 am

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]
March 3, 2018

Molecular therapy for body weight control, energy homeostasis and TIIDM: Lactulose (Brand names: Cholac, Generlac, Consulose, Duphalac), a non-absorbable sugar that aids in the treatment of constipation and hepatic encephalopathy,  decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 3/March/2017, 9.10 am

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by […]
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