Bio-Med Ideas

January 24, 2018

Molecular therapy for Metastatic cancers: Metformin, an anti-hyperglycemic drug, increases the expression of tumor suppressors CADM1 and RECK1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 25/January/2018, 12.03 am

From significance of the study to Public health relevance:  Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
January 23, 2018

Molecular therapy for Diabetic nephropathy (DN): Valsartan(Trade name: Diovan), an angiotensin converting enzyme inhibitor used in the treatment of hypertension, increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 23/January/2018, 11.59 pm

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may protect against the […]
January 23, 2018

Combinatorial therapy for blood-stage Plasmodium infection: A therapeutic mix encompassing Rilpivirine(RP) and Aspirin (ASP) (RPASP) decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 23/January/2018, 11.51 pm

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]
January 23, 2018

Natural product-based exercise mementics therapy for Metabolic disease: (-)-Epicatechin, isolated from Thunder god vine, increases PPARδ  and Foxo1 levels, inhibits glucose catabolism, preserves glucose levels, stimulates FA catabolism, delays the onset of hypoglycemia and boosts endurance exercise via down regulation of its target gene, 23/January/2018, 11.38 pm

Introduction: What they say  A study from Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA shows […]
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