Bio-Med Ideas

January 20, 2018

Molecular therapy for pulmonary arterial hypertension: Tadalafil [Brand name: Cialis, Adcirca and others], a cGMP-specific phosphodiestrase type 5 inhibitor used in the treatment of erectile dysfunction and pulmonary arterial hypertension, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 20/January/2018, 11.33 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]
January 20, 2018

Molecular therapy for tuberculosis: Sildenafil, a drug used in the treatment of erectile dysfunction and pulmonary arterial hypertension, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 20/January/2018, 11.26  pm

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]
January 20, 2018

Anti-infective Therapy:  A pharmaceutical mixture encompassing Azithromycin and Aspirin inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 20/January/2018,  11.07 pm

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]
January 20, 2018

Natural product-therapy for Deafness: A therapeutic mix encompassing Tadalafil, Cholecalciferol, Ajoene and DIM (TCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 20/January/2018, 10.57 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product-therapy for Deafness: A therapeutic mix encompassing Tadalafil, Cholecalciferol, Ajoene and DIM (TCAD)  increases the expression […]
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